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Wednesday, November 25, 2020 | History

2 edition of Regulation of the vascular endothelium found in the catalog.

Regulation of the vascular endothelium

J. M. Boeynaems

Regulation of the vascular endothelium

signals and transduction mechanisms

by J. M. Boeynaems

  • 96 Want to read
  • 21 Currently reading

Published by R.G.Landes, CRC Press is the exclusive worldwide distributor of the Molecular Biology Intelligence Unit in Austin, Boca Raton, FL .
Written in English

  • Vascular endothelium -- Molecular aspects.,
  • Cellular signal transduction.,
  • Endothelium, Vascular -- physiology.,
  • Signal Transduction -- physiology.,
  • Ion Channels -- physiology.,
  • Calcium -- metabolism.

  • Edition Notes

    Includes bibliographical references and index.

    StatementJean-Marie Boeynaems, Sabine Pirotton.
    SeriesMolecular biology intelligence unit, Molecular biology intelligence unit (Unnumbered)
    ContributionsPirotton, Sabine, 1964-
    LC ClassificationsQP88.45 .B64 1994
    The Physical Object
    Pagination117 p. :
    Number of Pages117
    ID Numbers
    Open LibraryOL1084839M
    ISBN 101570590265
    LC Control Number94008679

    Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells. Cardiovasc. Res. 41, – doi: /S(98) In previous studies, the endothelial-specific mitogen vascular endothelial growth factor (VEGF) was shown to be up-regulated in the stromal cells, the putative neoplastic cells in hemangioblastomas. Therefore, it was suggested that secretion of VEGF by stromal cells is the pathogenetic cause of the vascular lesions in hemangioblastomas. Cxsilenced HsT cells grew faster and were more migratory. Finally, Western blot analysis revealed that down-regulation of Cx43 resulted in decreased expression of thrombospondin-1, an antiangiogenesis molecule, and increased expression of vascular endothelial growth factor.

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Regulation of the vascular endothelium by J. M. Boeynaems Download PDF EPUB FB2

Regulation of the Vascular Endothelium: Signals and Transduction Mechanisms (Molecular Biology Intelligence Regulation of the vascular endothelium book by Jean-Marie Boeynaems (Author), Sabine Pirotton (Author)Cited by: 3.

Regulation of Endothelial Barrier Function - NCBI Bookshelf. The vascular endothelium lining the inner surface of blood vessels serves as the first interface for circulating blood components to interact with cells of the vascular wall and surrounding extravascular by: The term “endothelium-dependent responses” was coined after the seminal work of Robert Furchgott in [], although endothelium-derived vasoactive substances have been identified previously (e.g., prostacyclin, adenosine).

However, it was only after this princeps publication that the fundamental role of the endothelial cells in controlling the tone of the underlying vascular smooth Cited by: 3. In addition to regulating blood delivery and perfusion, a major function of vascular endothelia, especially those in exchange microvessels (capillaries and postcapillary venules), is to provide a.

ISBN: OCLC Number: Description: xv, pages: illustrations ; 24 cm: Contents: "Endothelium-Derived Relaxing Factor Endothelium-Dependent Vascular Responsiveness: Evolutionary Aspects, Virginia M. Miller and Paul M. Vanhoutte Endothelium-Dependent Relaxation and the Discovery of the L-Arginine: NO Pathway, Salvador Moncada and.

Title:Regulation of Vascular Endothelium Inflammatory Signalling by Shear Stress VOLUME: 14 ISSUE: 2 Author(s):Mustafa Zakkar, Gianni D Angelini and Costanza Emanueli Affiliation:Bristol Heart Institute, Bristol Royal Infirmary, level 7, Upper Maudlin Street, Bristol BS2 8HW., Bristol Heart Institute, Bristol Royal Infirmary, level 7, Upper Maudlin Street, Bristol BS2 by: 1.

Endothelial Nitric Oxide 2. The Endothelin System: Physiology 3. Cyclooxygenase-dependent Endothelium-derived Contracting Factors 4. Endothelium-derived Hyperpolarising Factor 5. Regulation of Blood Cell Function by Endothelial Cells 6. Hypertension 7. Endothelial Control of Vascular Tone in Chronic Heart Failure 8.

Endothelial dysfunction is now regarded as an early marker of vascular disease and therefore an important target for therapeutic intervention and discovery of novel treatments.

Ideal for both basic and clinical scientists, whether in industry or academia, and physicians, Vascular Endothelium in Human Physiology and Pathophysiology provides an up-to.

Endothelium dependent vasodilation: NO and other mediators 9. Endothelial vasoconstrictor substances produced by the endothelium Cellular redox pathways in endothelial dysfunction Regulation of the vascular endothelium book vascular diseases Blood coagulation and Endothelium Genetics of Endothelium Epigenetic regulation of endothelial function Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase.

Xavier Cullere, Xavier Cullere. From the Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. ISBN: OCLC Number: Description: pages: illustrations ; 27 cm. Contents: Multiplicity of endothelial cell functions and regulatory mediators --Nonthrombogenicity of the endothelial surface --Endothelium as a permeability barrier --Leukocyte adhesion and extravasation --Control of vessel tone and myocardial contraction --Metabolic functions of the.

Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside provides a detailed understanding of the endothelium, its activation and their link to some common clinical disorders.

In addition, the book covers earlier discoveries. Endothelial Mechanisms Regulating Blood Flow. Since the s, the vascular endothelium has been known to have an important role in the regulation of smooth muscle function and in modulating leukocyte and platelet adhesion to the endothelium.

As shown in the figure, various blood borne substances that come in contact with vascular endothelial cells (EC) cause the production and release of endothelial. Vascular endothelium of the brain has a multitude of regulatory functions that impact vascular tone, inflammatory responses, oxidative stress, angiogenesis, and thrombosis and hemostasis.

Brain capillary endothelium is the critical interface of the blood–brain barrier, with a wide range of specific functional and structural components.

Transcriptional regulation of vascular endothelial cell responses to endothelial cells, leading to angiogen-esis. To determine whether HIF-1 also mediates cell-autonomous responses to.

Although it is a simple, single layer of cells, the vascular endothelium is considered an active organ that responds to and secretes chemical signals. The vascular endothelium regulates the passage of substances and cells from the blood to the tissues and is central to the regulation of vascular tone (the balance between blood vessel constriction and dilation).

Daniel R. Machin, Hirofumi Tanaka, in Dairy in Human Health and Disease Across the Lifespan, Impact of Dairy Consumption on Vascular Endothelial Function. An additional factor underlying modulation of vasoconstrictor tone is the function of the vascular endothelium (Luscher and Barton, ).The vascular endothelium is a cellular monolayer that lines the inner lumen of the arterial.

Importantly, endothelin (ET), a vascular endothelium-derived growth factor was found to be significantly increased in the aged endothelium [60,61,62]. ET mainly acts through its receptors ET-A and ET-B present on endothelial as well as vascular smooth muscle cells (VSMCs).

Loss of endothelial normal function or structural integrity results in acute thrombosis, or chronic vascular changes that predispose to thrombosis among a variety of diseases, such as atherosclerosis, restenosis, diabetes mellitus, obesity, etc.

70 – 73 Understanding the mechanism by which endothelium regulates thrombosis not only provides. Further discussion focuses on the signaling and molecular mechanisms of endothelial barrier responses to various stimulations or drugs, as well as their relevance to several common clinical conditions.

Taken together, this book provides a comprehensive analysis of microvascular endothelial Cited by: Functional Ultrastructure of the Vascular Endothelium: Changes in Various Pathologies Development of the Endothelium.

Pages Suburo, A. (et al.) Preview. Transport Across the Endothelium: Regulation of Endothelial Permeability. *immediately available upon purchase as print book shipments may be delayed due to the COVID Vascular endothelial growth factor (VEGF) is an endothelial-cell-specific mitogen.

The finding that VEGF was potent and specific for vascular endothelial cells and, unlike bFGF, freely diffusible, led to the hypothesis that this molecule plays a unique role in the regulation of physiological and pathological angiogenesis (Ferrara and Henzel.

Vascular endothelium actively participates in inflammatory reactions in the majority of chronic respiratory diseases. Smoking is a major risk factor for bronchopulmonary diseases, and it plays an important role in endothelial dysfunction development.

Some experiments prove that aggressive pollutants of tobacco smoke (benzopyrene, peroxynitrite, acrolein, cyanides, peroxides, etc.) can. Endothelial regulation of vascular tone. Una S. Ryan, Gabor M.

Rubanyi, New York,Marcel Dekker Inc., pages, $ The endothelium lines the luminal surface of the blood vessel. This tissue is only one cell-layer thick, but it exerts a major influence on blood vessel tone, vascular. During an extended sabbatical of the pupil in Boston inwe probed together the concept that endothelial dysfunction served as a common denominator of vascular disease, with the balance between inflammation and its inhibition as a fulcrum of the regulation of the behavior of endothelial cells.

0 by The American Society for Biochemistry and Molecular Biology, Inc. THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. No. 36, Issue of Decem pp.Printed in U. S.A. Dual Regulation of Vascular Endothelial Growth Factor Bioavailability by Genetic and Proteolytic Mechanisms* (Received for publication, J ).

The formation of complete and well-functioning endothelium is critical for the success of tissue-engineered vascular grafts yet remaining a fundamental challenge.

Endothelium remodeling onto the lumen of tissue-engineered vascular grafts is affected by their topographical, mechanical, and biochemical characteristics. For meeting multiple requirements, composite strategies have recently.

Endothelial cells play an important role in maintaining homeostasis, and disruption of the endothelial barrier have been linked to a number of different pathologies, including cancer metastasis.

The vascular endothelial barrier is known to be regulated by a variety of factors, including sphingosinephosphate (S1P), a bioactive lipid metabolite, which has been shown to improve barrier function. Edited by two brilliant cardiovascular clinicians, this book embraces the basis of endothelial involvement in vascular disease and continues to elucidate risk factors, diagnostic tools and markers, and has a major section on prevention and therapy.

This book represents the bridge from the laboratory to bedside. Vascular endothelial growth factor (VEGF) is one of the most potent and specific angiogenic factors.

The physiologic roles of VEGF in humans include neovascularization and endometrium implantation, and in pathological processes VEGF has been involved in the initation, growth, and metastasis of tumors. Structure. The endothelium is a thin layer of single flat cells that line the interior surface of blood vessels and lymphatic elium is of mesodermal origin.

Both blood and lymphatic capillaries are composed of a single layer of endothelial cells called a monolayer. In straight sections of a blood vessel, vascular endothelial cells typically align and elongate in the direction of.

Endothelial regulation of vascular tone Una S. Ryan, Gabor M. Rubanyi, New York,Marcel Dekker Inc., pages, $ The endothelium lines the luminal surface of the blood vessel.

This tissue is only one cell-layer thick, but it exerts a major influence on blood vessel tone, vascular growth. Dual Regulation Of Cofilin-1 Activity By LIM Kinase And Slingshot-1L Phosphatase Mediates Thrombin-Induced Actin Dynamics And ICAM-1 Expression In Endothelial Cells Fabeha Fazal, Kaiser M.

Bijli, Jacob N. Finkelstein, and Arshad Rahman. Thrombomodulin (TM) is a amino acid protein with a broad cell and tissue distribution consistent with its wide-ranging physiological roles.

When expressed on the lumenal surface of vascular endothelial cells in both large vessels and capillaries, its primary function is to mediate endothelial th. The master regulator of vascular growth is vascular endothelial growth factor-A (VEGF).

Already, only a few years after its isolation and molecular cloning [ 2, 3 ], the first uncontrolled clinical attempts to induce therapeutic angiogenesis with its gene delivery were reported in PAD or CAD patients [ 4, 5 ], generating great excitement.

The vascular endothelium is a monolayer of cells between the vessel lumen and the vascular smooth muscle cells.

Nitric oxide (NO) is a soluble gas continuously synthesized from the amino acid L-arginine in endothelial cells by the constitutive calcium-calmodulin.

Regulation of Cerebral Blood Vessels by Humoral and Endothelium-Dependent Mechanisms Update on Humoral Regulation of Vascular Tone Frank M. Faraci and Donald D. Heistad Recent studies suggest that humoral and endothelium-dependent mechanisms may play an important role in the cerebral circulation.

Angiotensin may acutely and chronically increase. Vascular endothelial growth factor (VEGF) is the major molecule governing angiogenesis, defined as the growth of blood vessels from vascular structure.

There is abundant evidence that nitric oxide (NO) is an effector molecule mediating the activity of VEGF. Recent studies have revealed a critical role for both extracellular matrices and matrix metalloproteinases in the molecular control of vascular morphogenesis and stabilization in three-dimensional (3D) tissue environments.

Key interactions involve endothelial cells (ECs) and pericytes, which coassemble to affect vessel formation, remodeling, and stabilization events during development and.

Zeb1-regulation of NV is not through regulation of Vegf genes. VEGF-regulation of angiogenesis is a well-known mechanism to initiate and promote. Heregulin (HRG) belongs to a family of polypeptide growth factors that bind to receptor tyrosine kinases ErbB3 and ErbB4.

HRG binding induces ErbB3 and ErbB4 heterodimerization with ErbB2, activating downstream signal transduction. Vascular endothelial growth factor (VEGF) is a primary regulator of physiological angiogenesis and is a major mediator of pathological angiogenesis, such as tumor.Extracellular purines and pyrimidines (ATP, ADP, UTP and adenosine) are released into the extracellular milieu in response to a variety of stress conditions and act as important regulators of vascular.To further investigate the molecular mechanisms underlying this observation, we exposed human SVs and IMAs to adiponectin ex vivo and observed a rapid PI3/Akt-mediated increase in eNOS phosphorylation at Ser, which is known to activate the enzyme.

15 Although eNOS is the source of NO in the vascular endothelium, deficiency of its cofactor.